Cannabinoids

Cannabinoid CB1-receptor mediated regulation of gastrointestinal motility in mice in a model of intestinal inflammation Angelo A Izzo,1* Filomena Fezza,2 Raffaele Capasso,3 Tiziana Bisogno,2 Luisa Pinto,1 Teresa Iuvone,1 Giuseppe Esposito,1 Nicola Mascolo,1 Vincenzo Di Marzo,2 and Francesco Capasso1 11Department of Experimental Pharmacology, University of Naples “Federico II”, via D. Montesano 49, 80131 Naples Italy 22Institute […]

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MAURIZIO BIFULCO,*,†,2 CHIARA LAEZZA,* GIUSEPPE PORTELLA,* MARIO VITALE,* PIERANGELO ORLANDO,‡ LUCIANO DE PETROCELLIS,§ AND VINCENZO DI MARZO††,2 *,†,‡,§,††Endocannabinoid Research Group, *Centro di Endocrinologia ed Oncologia Sperimentale, Consiglio Nazionale delle Ricerche, and Dipartimento di Biologia e Patologia Cellulare e Molecolare ‘L. Califano’, Universita` di Napoli Federico II, †Dipartimento di Medicina Sperimentale e Clinica ‘G. Salvatore’, Universita` […]

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My pet lobster has been regularly consuming some smoking blend and found out that some variety would give him some intense munchies. This effect is sought after by my lobster as it is currently trying to put on some weight and has naturally low appetite. My lobster also experienced a strong sedative effect associated with […]

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My pet lobster has been regularly consuming some smoking blend and found out that some variety would give him some intense munchies. This effect is sought after by my lobster as it is currently trying to put on some weight and has naturally low appetite. My lobster also experienced a strong sedative effect associated with […]

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Cannabinoid receptors involved in placebo analgesia. Placebo analgesia is mediated by both opioid and nonopioid mechanisms, but so far nothing is known about the nonopioid component. Here we show that the specific CB1 cannabinoid receptor antagonist 5-(4-chlorophenyl)-1-(2,4-dichloro-phenyl)-4-methyl-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide (rimonabant or SR141716) blocks nonopioid placebo analgesic responses but has no effect on opioid placebo responses. These findings […]

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by Joost Wiskerke, Nicky Stoop, Dustin Schetters, Anton N. M. Schoffelmeer, Tommy Pattij It is well known that acute challenges with psychostimulants such as amphetamine affect impulsive behavior. We here studied the pharmacology underlying the effects of amphetamine in two rat models of impulsivity, the 5-choice serial reaction time task (5-CSRTT) and the delayed reward […]

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Methods of the pharmacological imaging of the cannabinoid system (PhICS) study: towards understanding the role of the brain endocannabinoid system in human cognition. Int J Methods Psychiatr Res. 2011 Mar;20(1):10-27 Authors: van Hell HH, Bossong MG, Jager G, Kahn RS, Ramsey NF Abstract Various lines of (pre)clinical research indicate that cannabinoid agents carry the potential […]

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Severe Toxicity Following Synthetic Cannabinoid Ingestion. Lapoint J et al. Clin Toxicol 2011;49:760-764. Abstract  This case report des ribes a 48-year-old man who developed seizures within 30 minutes of ingesting a mixture of ethanol and a synthetic cannabinoid (which was later identified as the synthetic cannabinoid JWH-018).  The patient also required cardioversion on the first hospital day […]

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The endogenous cannabinoid 2-arachidonoylglycerol is intravenously self-administered by squirrel monkeys. J Neurosci. 2011 May 11;31(19):7043-8 Authors: Justinová Z, Yasar S, Redhi GH, Goldberg SR Abstract Two endogenous ligands for cannabinoid CB1 receptors, anandamide (N-arachidonoylethanolamine) and 2-arachidonoylglycerol (2-AG), have been identified and characterized. 2-AG is the most prevalent endogenous cannabinoid ligand in the brain, and electrophysiological […]

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The endogenous cannabinoid 2-arachidonoylglycerol is intravenously self-administered by squirrel monkeys. J Neurosci. 2011 May 11;31(19):7043-8 Authors: Justinová Z, Yasar S, Redhi GH, Goldberg SR Abstract Two endogenous ligands for cannabinoid CB1 receptors, anandamide (N-arachidonoylethanolamine) and 2-arachidonoylglycerol (2-AG), have been identified and characterized. 2-AG is the most prevalent endogenous cannabinoid ligand in the brain, and electrophysiological […]

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The endogenous cannabinoid 2-arachidonoylglycerol is intravenously self-administered by squirrel monkeys. J Neurosci. 2011 May 11;31(19):7043-8 Authors: Justinová Z, Yasar S, Redhi GH, Goldberg SR Abstract Two endogenous ligands for cannabinoid CB1 receptors, anandamide (N-arachidonoylethanolamine) and 2-arachidonoylglycerol (2-AG), have been identified and characterized. 2-AG is the most prevalent endogenous cannabinoid ligand in the brain, and electrophysiological […]

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Nonopioid placebo analgesia is mediated by CB1 cannabinoid receptors. Nat Med. 2011 Oct 2; Authors: Benedetti F, Amanzio M, Rosato R, Blanchard C Abstract Placebo analgesia is mediated by both opioid and nonopioid mechanisms, but so far nothing is known about the nonopioid component. Here we show that the specific CB1 cannabinoid receptor antagonist 5-(4-chlorophenyl)-1-(2,4-dichloro-phenyl)-4-methyl-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide […]

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The Ministry of Health ignored advice from police and Customs that legislation to ban synthetic cannabis products was incomplete and could lead to the re-emergence of near-identical legal highs. It was revealed this week that a new legal version of Amsterdam Cafe, a synthetic cannabis product, had gone on …read more at http://www.odt.co.nz/news/national/180975/ministry-ignored-cannabinoid-warning

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