Cannabinoids

Approximately 25% of immunocompromised HIV patients smoke marijuana for its putative therapeutic benefit. The goal of these studies was to test the hypothesis that marijuana-derived cannabinoids have immunomodulatory effects on HIV antigen-specific T cell effector function. A surrogate mouse model to induce polyclonal T cell responses against HIVgp120 was established. THC, a marijuana-derived cannabinoid, suppressed or […]

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Bagher, Amina M. The pharmacological functions of the type 1 human cannabinoid receptor (hCB1) are thought to be modulated through the isoform encoded by the fourth exon of the CNR1 gene. Two other mRNA variants of the coding region of this receptor have been described, hCB1a and hCB1b. The contribution of these variants to endocannabinoid […]

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SOURCE Neurodegenerative disorders carry a significant social and economic burden, and the effective treatment of such illnesses remains a challenge for neuroscientists and neurologists. Although significant advances have been made on our understanding of the molecular mechanisms underlying neurodegenerative diseases, the translation of this knowledge into effective therapeutic treatments has been limited. There is still […]

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University of Washington reports… “American megachurches use stagecraft, sensory pageantry, charismatic leadership and an upbeat, unchallenging vision of Christianity to provide their congregants with a powerful emotional religious experience, according to research from the University of Washington. “The megachurches movement is one of the leading indicators of how American Christians exercise their faith these days, […]

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The cool new site Weedist.com got my attention by publishing this amazingly detailed chart that lists not only the cannabinoids in our favorite plant, but also their boiling temperatures in both Celsius and Fahrenheit, effects and cautions, and even terpenes and toxins for good measure. Best of all, you can click the top of any […]

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Riffat Tanveer, Niamh McGuinness, Stephanie Daniel, Aoife Gowran, Veronica A. Campbell* Neurodegenerative disorders carry a significant social and economic burden, and the effective treatment of such illnesses remains a challenge for neuroscientists and neurologists. Although significant advances have been made on our understanding of the molecular mechanisms underlying neurodegenerative diseases, the translation of this knowledge […]

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Description Testing medical marijuana for cannabinoid content is rapidly becoming a standard practice. A full scientific analysis of flowers, edibles, and concentrates benefits the entire medical marijuana community from the patient to the grower and everyone in between. As a dispensary, both you and the patient benefit by knowing that their medicine is suited for […]

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O-1602 is a cannabidiol analogue that does not bind with high affinity to either the cannabinoid CB1 receptor or CB2 receptor. However, there is evidence that O-1602 has significant effects in the central nervous system as well as other parts of the body. Depending upon the model, O-1602 has anti-inflammatory or pronociceptive effects, mediated through […]

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Abstract Cannabinoid receptor agonists produce reliable antinociception in most preclinical pain assays but have inconsistent analgesic efficacy in humans. This disparity suggests that conventional preclinical assays of nociception are not sufficient for prediction of cannabinoid effects related to clinical analgesia. To extend the range of preclinical cannabinoid assessment, this study …read more at http://jpet.aspetjournals.org/content/early/2012/08/14/jpet.112.197780.short

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Zahida Qamri, Anju Preet and Ramesh Ganju Department of Pathology, Ohio State University, Columbus, OH, Lombardi Comprehensive Cancer Center, Washington, DC Breast cancer is the most common cause of cancer deaths in women worldwide. The metastatic spread of breast tumors accounts for the majority of cancer-related deaths and these tumors fail to respond to conventional therapies due to drug resistance and toxicity. […]

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Nam DH, Lee MH, Kim JE, Song HK, Kang YS, Lee JE, Kim HW, Cha JJ, Hyun YY, Kim SH, Han SY, Han KH, Han JY, Cha DR  Endocrinology. 2012 Mar; 153(3):1387-96 Department of Internal Medicine, Korea University, Ansan City, Kyungki-Do, 425-020, Korea. The endocannabinoid system is important in the pathogenesis of obesity-related metabolic disorders. However, the effect of […]

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