About 7000 cases of toxicities associated with synthetic cannabinoids (ie synthetic marijuana, K2, or Spice) are reported annually to US poison control centers, and that reportedly accounted for two-thirds of overall substance abuse between 2005 and 2011.
Synthetic cannabinoids were first introduced in the United States in 2008 but have been used in Europe since 2004. They are classified as a Class I controlled substance by the Drug Enforcement Administration.
Natural marijuana consists of an active ingredient known as delta-9- tetrahydrocannabinol (THC), which is one of the most psychoactive cannabinoid, whereas synthetic cannabinoids are analogs of natural marijuana that are chemically synthesized. These