Cannabinoid Agonist May Prevent Opioid Addiction

A drug compound previously shown to be safe for use in people may prevent opioid tolerance and physical dependence when used in combination with opioid-based pain medications, a new study in mice indicates.

Researchers have discovered that the CB2 cannabinoid agonist LY2828360, a drug previously tested to treat osteoarthritis pain appears to block neuropathic pain and decrease signs of opioid dependence.

When drug manufacturer Eli Lilly and Co. conducted human clinical trials of the drug to treat osteoarthritis pain, they found that the drug lacked efficacy. Researchers had not, however, tested the drug’s more at