Cannabis was added to the U.S. pharmacopeia (USP) in 1851, which has been used since the 1820s to identify and standardize prescription and over-the-counter drugs for medical use. Back then, the USP was comprised almost entirely of botanical drugs. From 1850 to 1937, “Extractum Cannabis,” or hemp extract, was used for a wide range of outcomes, including exhilaration, aphrodisia, sleep, increasing appetite, and to relieve pain, spasms, and constipation. It was removed from the book in 1942, but reemerged in later years in fractionated pharmaceutical medications. Modern examples are Marinol and Cesamet.
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